When Bruce Blackwood, 55 and from Queens, New York, called out of work and said he fell in the shower, then seemingly vanished, his family and police knew something was wrong.
A Hooters-obsessed woman and a former Navy SEAL were accused of murdering a Virginia-based couple and dismembering the bodies on vacation in Ocean City, Maryland.
Cash App founder Bob Lee’s fatal stabbing in San Francisco sparked talk of a possible random robbery gone wrong, but police and his loved ones almost immediately suspected that wasn't the case.
Just a year after Chad Daybell and Lori Vallow met, four people would be dead in a story Dateline correspondent Keith Morrison dubbed "as strange and disturbing as any we have ever told."
Taylor Wright was hoping to start a new chapter with her girlfriend when she disappeared, but she was never seen alive again after a day out with "friend" Ashley McArthur.
After Jonathan Crupi called 911 to say he arrived home to find his wife dead, authorities discovered that Simeonette Mapes-Crupi had been pushed down a flight of stairs and stabbed 15 times.
The gruesome murder of the aspiring actor and filmmaker who was popular in New York City's club scene inspired several works, including the 2003 film Party Monster.
After an elderly socialite vanished from her New York City brownstone, Sante Kimes and her son Kenny were arrested, revealing decades of crime, deception and murder.
Kelly Connell's mom and brother Joseph Connell conspired to replace the diamonds in her engagement ring with fakes, which initially led investigators to mistakenly believe she was responsible for two murders.
Jimmy Allan told police he found his wife hanging from an extension cord in their Michigan basement and she tried to "kill herself," but investigators discovered Amy Allan didn't take her own life.
In the two-hour Prosecuting Evil season premiere, Siegler addressed the 1999 murder of expectant mother Belinda Temple and accusations of prosecutorial misconduct.