It Takes A Killer profiles a serial killer who claims he's behind the infamous murder of Nicole Brown Simpson and Ronald Goldman.

The discovery of a Jane Doe underneath a New Jersey bridge kick starts an intensive investigation to figure out who she is and how she died. Law enforcement uses forensic evidence and eyewitnesses to solve the mystery and bring a murderer to justice.

Police follow the trail of a young Southern California woman who vanishes without a trace. Authorities work the missing person investigation for years until a random encounter turns them onto a chilling discovery and an even colder criminal.

 A serial predator terrorizes Southeastern Louisiana strangling men to death and disposing of their bodies. This killer gets away with murder for nearly a decade until a victim escapes his clutches and then leads police right to the killer's doorstep.